Excess Fat Storage and Obesity

A team of scientists at the Gladstone Institutes and Yale University have begun to unravel the complex process by which cells take in and store microscopic fat molecules, suggesting new directions for further research into solutions for obesity and its related conditions, such as heart disease, type 2 diabetes and fatty liver disease.

In a paper being published October 4 in Cell Metabolism, Gladstone Senior Investigator Robert Farese, Jr., MD, and Yale University Associate Professor Tobias Walther, PhD, detail the critical role an enzyme called CCT plays in separating and storing fat molecules safely in each cell. When CCT malfunctions and the process fails, the molecules fuse together into ever-larger and toxic globules that can build up throughout the body and in the liver.

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